Products and Services

Discovery Biology

Albany Molecular Research Inc.'s (AMRI) Discovery Biology team can accelerate your program toward the ultimate goal, which is to move compounds to the clinic and toward commercialization. Working with AMRI for your Discovery Biology work means lower costs, shorter time cycles and better outcomes for you.

AMRI's Discovery Biology capabilities include:

  • Reagent generation – recombinant proteins and cell lines
  • Assay development
  • 'Hit-finding' High-Throughput Screening (HTS) – conventional screening, high-content imaging and label-free
  • Fast-track Hit-to-Lead & Lead Optimization medicinal chemistry
  • Structure-based drug design – Computer Aided Drug Discovery (CADD) or crystallography
  • In vitro pharmacology – off-target activities and safety targets
  • In vitro DMPK, bioanalysis, pharmacokinetics (PK)
  • Physicochemical properties and permeability
  • Metabolic stability and metabolite identification, reactive metabolite screening
  • CYP phenotyping, inhibition and induction
  • Antibody Drug Conjugate optimization (warhead, linker and conjugation condition)

Other advantages include:

  • Synergies with AMRI network sites (e.g. formulation, salt screen, analytical methods)
  • Seamless transition across every step of your project
  • Global facilities and an integrated approach maximizes value through a blended cost structure, smoother logistics, and a single point of contact
  • Fully-integrated projects
  • You provide the target, AMRI returns a list of profiled compounds
  • Activity on primary target plus off-target activities (selectivity and safety)
  • Metabolic liabilities
  • PK profile